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Silver Preparations: The History and Development

Over thousands of years civilizations throughout the world have used silver as a healing and anti-bacterial agent. Its medical, preservative and restorative powers can be traced as far back as the ancient Greek and Roman Empires. In recent history, silver preparations have been used for treatment and prevention of disease and infection. During times as late as the 1930's, Doctors were using silver as a germicide and antibiotic before the advent of modern antibiotics.

Consider these interesting facts:


In their earliest usage, silver-based remedies were prepared in the form of silver salts, e.g. silver nitrate and silver acetate. Later, non-salt preparations have been included such as, silver sulfadiazine and colloidal silver. All of these remedies have been used primarily to treat infectious conditions.

Generally, the silver salt remedies have shown limited effect, usually requiring relatively high doses to achieve any effect. High dosages of such silver salts – especially after regular, long-term use – has produced reportable cases of silver toxicity, known as Argyria. On the other hand, low concentration silver colloid preparations are not associated with any reportable toxicity.

Argyria is characterized as a permanent ashen-gray (bluish) discoloration of the skin, conjuctival sclerae, and internal organs, resulting from long-continued use of high concentration silver salts – without any otherwise notable adverse effects on general metabolic health. Today it is difficult to find reference to Argyria in any standard medical textbook.

Recently, the use of low concentration, i.e., < 50 ppm, non-proteinaceous silver colloids have been found to be tremendously effective against localized cutaneous and upper respiratory infections. The levels of this silver colloid required to achieve satisfactory antimicrobial action are 100 times lower than that of the previously used silver salts or protein colloids. There has been no reported toxicity or adverse events linked to the use of these low concentration, pure silver colloids.